Ticagrelor causes false-negative functional tests for heparin-induced thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Heparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
متن کاملLaboratory tests for the diagnosis of heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is associated with high morbidity and mortality. Because the pathophysiology of this complex disorder has remained unclear, so has the development of supportive diagnostic laboratory assays. The currently available laboratory methods for HIT diagnosis include several platelet function assays: the platelet aggregation assay, platelet aggregation with simult...
متن کاملHeparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/heparin antibodies devel...
متن کاملHeparin induced thrombocytopenia
Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa inhibitors, thrombin inhibito...
متن کاملHeparin-induced Thrombocytopenia
Nebojša M. Antonijević1, Nebojša Radovanović1, Slobodan Obradović2, Dragica Vučelić6, Bojan Stojanović1, Danijela Miković4, Mirjana Kovač4, Tina Kočica1, Svetlana Tadić4, Irina Antonijević4, Snežana Drašković4, Valentina Djordjević5, Branko Čalija6, Jovan Peruničić1, Zorana Vasiljević1 1 Institute of Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia; 2 Clinic of Emergency Med...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2019003582